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KMID : 0614020040190010043
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Journal of Pharmaceutical Sciences (C.N.U.)
2004 Volume.19 No. 1 p.43 ~ p.47
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Evaluation for water retaining effects and moisturizing effects of Topical gel formulations by various additives
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Lee Eun-Mi
Park Jong-Hee
Kyong Kee-Yeol
Jeon Il-Soon
Cho Hye-Jung
Jee Ung-Kil
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Abstract
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The aim of this study was to improve the moisturizing and water retaining effects of a gel containing poloxamer 407, glycerin, sod hyaluronate, sorbo(sorbitol 70%). Topical preparations were formulated as a gel containing different concentration poloxamer 407, glycerin, sod. hyaluronate, sorbo(sorbito1 70%), lipid(ceramide. sphingosine ratio 1:l). We tested a various combination of different additives for the moisturizing effect The water holding capacity of the mixture was measured using a moisture analyzer. In vivo test was carried out on human skin using Skicon-200 and water retaining effect was increased by addition of lipid. Water evaporation test was performed by various concentration of additives and water evaporation characteristics of the preparations were determined using the moisture analyzer. Moisturizing and water retaining effects was increased by adequate combination of various additives with topical gel formulations.
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KEYWORD
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Topical gel formulation, moisturizing effects, water retaining effects, moisture analyzer, Skicon-200
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